Dr. Talkowski directs the Genomics and Technology Core of MGH, which offers molecular and computational genomics services for scientific collaborations relevant to the overall mission of the research program.  A list of routine services is provided below, though the G&T Core capabilities include an array of additional applications.  Pricing is based on project size and effort, and the overall core is cost neutral.  Please contact the G&T Core with interest in getting a project quote.

Molecular Genomics and
Bioinformatic Analysis

  • Whole genome sequencing
  • Large-insert jumping library sequencing
  • RNAseq (polyA selection or ribodepletion)
  • Whole Exome sequencing
  • Targeted capture sequencing (CapSeq)
  • ChIPseq
  • miRNAseq
  • Genome-wide structural variation detection
  • Characterization of transgenic integration
  • Genome-wide characterization of genome integrity following genome editing
  • Breakpoint characterization for chromosomal abnormalities
  • DNA and RNA extractions and quantification
  • Sample integrity analysis
  • Targeted capture probe design
  • CRISPR/Cas9 Genome Editing
  • shRNA genome editing

Genomics Equipment and Sequencing Available in Simches

  • Covaris E220
  • Agilent Tapestation 2200
  • Roche LightCycler 480
  • Illumina HiSeq 2500
  • Illumina HiSeq 2000
  • Illumina MiSeq


Michael Talkowski, Ph.D.Director
Ben Currall, Ph.D.Molecular Genomics
Katie O'KeefeMolecular Genomics
Serkan Erdin, Ph.D.Computational Genomics
Laura Smith, M.Sc.Project Manager