Dr. Talkowski directs the Genomics and Technology Core of MGH, which offers molecular and computational genomics services for scientific collaborations relevant to the overall mission of the research program. A list of routine services is provided below, though the G&T Core capabilities include an array of additional applications. Pricing is based on project size and effort, and the overall core is cost neutral. Please contact the G&T Core with interest in getting a project quote.

Molecular Genomics & Bioinformatic Analysis

  • Whole Genome Sequencing
  • Large-Insert Jumping Library Sequencing
  • RNAseq (polyA selection or ribodepletion)
  • Whole Exome Sequencing
  • Targeted Capture Sequencing (CapSeq)
  • ChIPseq
  • miRNAseq
  • Genome-Wide Structural Variation Detection
  • Characterization of Transgenic Integration
  • Genome-Wide Characterization of Genome Integrity Following Genome Editing
  • Breakpoint Characterization of Chromosomal Abnormalities
  • DNA and RNA Extractions and Quantification
  • Sample Integrity Analysis
  • Targeted Capture Probe Design
  • CRISPR/Cas9 Genome Editing
  • shRNA Genome Editing

Genomic Equipment & Sequencing Available

  • Covaris E220
  • Agilent Tapestation 2200
  • Roche LightCycler 480
  • Illumina HiSeq 2500
  • Illumina HiSeq 2000
  • Illumina MiSeq

People

Michael Talkowski, Ph.D.Director
Celine de Esch, Ph.D.Interim Core Director
Monica Salani, Ph.D.Project Manager
Serkan Erdin, Ph.D.Computational Genomics
Bimal Jana, Ph.D.Postdoctoral Fellow
Jack LemanskiResearch Technician II
Laura Smith, M.Sc.Administrator