Opportunities

We welcome inquiries from highly qualified scientists at all levels from graduate students to senior staff scientists interested in joining our research team and collaborative network to study the genomics of human disease.

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Current Opportunities:

We are seeking exceptional postdoctoral candidates in computational biology, bioinformatics, and/or statistical genetics. Candidates would direct collaborative research initiatives seeking to discover genomic variation and determine its functional impact in developmental anomalies and neuropsychiatric disorders. Highly qualified candidates would oversee one or more of the following studies: (1) analyses related to the aggregation of datasets across global populations to discover structural variation, principles of natural selection, and insights into population genetics (e.g. the genome aggregation database [gnomAD]); (2) large-scale Mendelian and complex disease association studies; (3) functional genomics analyses from human iPSC-derived neuronal cells or three-dimensional organoid models modified using CRISPR/Cas9 genome editing.

Please email Dr. Talkowski directly at mtalkowski@mgh.harvard.edu if you are interested in a Research Fellow position.

We are seeking exceptional postdoctoral candidates in computational biology, bioinformatics, and/or statistical genetics. We are seeking a candidate to perform genomics research across a spectrum of population genetics, disease association, and functional genomics studies. Successful candidates are expected to excel at critical thinking, be quick learners for new analytical approaches, and capable of applying or developing novel computational methods for solving complex problems. Candidates must have a doctoral degree (PhD or MD), an excellent publication record, and great communication skills. A strong background in computer science and/or mathematics is required; and specifically, experience with analyzing high-dimensional datasets is preferred. Some fluency with biology and/or neuroscience is ideal, as is the ability to adapt quickly to a cross-functional team in a rapidly changing environment.

Please email Dr. Talkowski directly at mtalkowski@mgh.harvard.edu if you are interested in a Research Fellow position.

We are seeking an experienced Research Scientist to lead an array of collaborative studies to perform CRISPR-based neuronal modeling of genetic alterations associated with autism spectrum disorder (ASD) and more broadly defined neurodevelopmental disorders (NDDs). The Talkowski Laboratory in the Center for Genomic Medicine at Massachusetts General Hospital (MGH), and the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, is seeking a motivated, enthusiastic, experienced leader to join our research teams. Our group explores the impact of genomic variation on human disease, with a particular focus on the relationship between genome structure and function in neurodevelopmental and neuropsychiatric disorders. We are also dedicated to the development and application of innovations in genome sequencing technologies and genetic diagnostics. The candidate will be expected to have experience, or high capacity to learn, mammalian cell culture, induced pluripotent stem cell (iPSC) modeling, CRISPR/Cas9 genome editing, and various molecular genetic techniques. The team will include the Principle Investigator and multiple junior faculty, PhD level Staff Scientists, postdoctoral fellows, research technicians and technologists, as well as graduate students. In this position we are seeking a Research Scientist with experience to lead projects, contribute to diverse and highly collaborative research programs, and provide training and oversight to junior scientists.

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We are seeking a research technician or technologist with a Bachelor’s degree in biology, biochemistry, or a related discipline. The candidate should have at least 1 year of experience in DNA/RNA extraction, PCR/qPCR, gel electrophoresis, mammalian cell culture, and genomic sequencing.

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We are seeking a highly motivated and enthusiastic candidate to help lead our research programs in the genomics of human disease. Our research team integrates molecular and computational genomics approaches to dissect the genetic architectures of a spectrum of human diseases and traits, with a particular focus on the relationship between genome structure and function. The research program is a highly collaborative environment within the MGH and Broad Institute, as well as across several national and international genomics consortia. We are seeking an extremely collaborative, dynamic, and highly organized project manager to facilitate the progress and success of both new and existing projects.  The ideal candidate will drive scientific, operational, and administrative processes across institutions and engage with PI(s) and teams on consortium-based projects. The candidate will also be deeply engaged with the Broad Institute Genomics Platform and the Data Science Platform as new capabilities and innovations are developed, as well as the Stanley Center Project Management team. An ideal candidate will have outstanding writing and communication skills and be capable of participating in research proposal development and progress reports.

Apply here.