We are seeking an experienced Research Scientist to lead an array of collaborative studies to perform CRISPR-based neuronal modeling of genetic alterations associated with autism spectrum disorder (ASD) and more broadly defined neurodevelopmental disorders (NDDs). The Talkowski Laboratory in the Center for Genomic Medicine at Massachusetts General Hospital (MGH), and the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, is seeking a motivated, enthusiastic, experienced leader to join our research teams. Our group explores the impact of genomic variation on human disease, with a particular focus on the relationship between genome structure and function in neurodevelopmental and neuropsychiatric disorders. We are also dedicated to the development and application of innovations in genome sequencing technologies and genetic diagnostics. The candidate will be expected to have experience, or high capacity to learn, mammalian cell culture, induced pluripotent stem cell (iPSC) modeling, CRISPR/Cas9 genome editing, and various molecular genetic techniques. The team will include the Principle Investigator and multiple junior faculty, PhD level Staff Scientists, postdoctoral fellows, research technicians and technologists, as well as graduate students. In this position we are seeking a Research Scientist with experience to lead projects, contribute to diverse and highly collaborative research programs, and provide training and oversight to junior scientists.