We have also led genomics efforts to identify genes disrupted by genomic rearrangements, particularly balanced chromosomal abnormalities (BCAs). Our previous studies have performed structural variation to discovery genes associated with autism spectrum disorder (ASD), related neurodevelopmental disorders, and psychiatric disorders. The precise mapping of balanced chromosomal breakpoints has provided a remarkable yield of novel genes for which haploinsufficiency represents a significant causal factor for early onset neurodevelopmental abnormalities. In our latest study, we aggregated 63,237 exomes (>20,000 ASD) to explore shared and distinct genes, mutations, and cellular expression patterns across ASD, developmental delay (DD), and schizophrenia (SCZ) cohorts. We leveraged all of this information and a powerful Bayesian analytic framework (TADA) to discover 71 genes contributing risk to ASD at a statistical threshold approximately equivalent to exome-wide significance (FDR<0.001), and 183 genes at FDR < 0.05 (paper found here).