A few members of the lab volunteered at the Doug Flutie Jr. Foundation STARS of the Spectrum Music Festival on August 3 at the Veterans Memorial Stadium in Quincy, MA. The festival is a sensory-friendly, inclusive event highlighting musicians and artisans with autism. The event was well attended, with over 100 performances for the thousands [...]
In a recently published manuscript, we demonstrated the potential impact of complex and cryptic chromosomal abnormalities in children with early onset neuropsychiatric disorders. In this study, we find that the mainstay of genetic testing for prenatal and pediatric developmental anomalies of unknown etiology, clinical microarray to detect copy number variants (CNVs), is insufficient to detect [...]
In two papers published in Cell Stem Cell in 2014, we demonstrated the genomic consequences of CRISPR/Cas9 genome editing technology, both at the targeted site of alteration and through genome-wide analyses to identify unintended mutagenesis through off-target effects. In both studies, our analyses suggest that the off-target effects of CRISPR/Cas9 are minimal, and that the [...]
